Top Alternatives to MLDonkey

eMule is a free peer-to-peer file sharing application for Microsoft Windows. Started in May 2002 as an alternative to eDonkey2000, eMule now connects to both the eDonkey network and the Kad network.

itTorrent is a communications protocol of peer-to-peer file sharing ("P2P") which is used to distribute data and electronic files over the Internet.

RetroShare is open source software for encrypted filesharing, serverless email, instant messaging, online chat, and BBS, based on a friend-to-friend network built on GNU Privacy Guard (GPG).

Soulseek is a peer-to-peer (P2P) file-sharing network and application.

Ares Galaxy is a P2P client that automatically finds more sources and downloads files from many users at once. Increase the speed of your downloads, and enjoy one of the most easy-to-use BitTorrent clients.

Calypso is a cross platfrom file sharing client using the anonymous network MUTE. Developed using C++ and Qt, Calypso is portable to Windows, Linux, and other environments.

Shareaza is a peer-to-peer file sharing client running under Microsoft Windows which supports the gnutella, Gnutella2 (G2), eDonkey, BitTorrent, FTP, HTTP and HTTPS network protocols and handles magnet links, ed2k links, and the now deprecated gnutella and Piolet links.