Top Alternatives to Plesk

Webmin is a web-based system configuration tool for Unix-like systems, although recent versions can also be installed and run on Windows.

ISPmanager is a web hosting & Linux server control panel for both dedicated server and VPS management.

Ajenti is an open source, web-based control panel that can be used for a large variety of server management tasks.

cPanel is a Linux-based web hosting control panel that provides a graphical interface and automation tools designed to simplify the process of hosting a web site.

OVIPanel is a freemium control for web hosting.

ServerPilot.io provides a way to run WordPress and PHP sites. Simple, fast, secure hosting on your DigitalOcean servers.

Vesta uses latest and greatest versions and depending on avaiable system resources it delivers optimized configuration for Low/Medium/High RAM server types.

ISPConfig is an open source hosting control panel for Linux.

Cloudron is a platform to host apps on your server and keep them up-to-date and secure.

ZPanel is a free and complete web hosting control panel for Windows and POSIX (Linux, UNIX and MacOSX) based servers.

Univention Corporate Server lets you manage server applications and IT infrastructures.

Sentora is an open-source web hosting control panel built specifically to work on a variety of Linux distributions.

Virtualmin is a domain hosting and website control panel, which gives the ability to create and manage many domains and is available in both open source and commercial versions.

Froxlor is a server management panel with lightweight server management software.

Kloxo (Lxadmin) was a free and open-source web hosting control panel for the Red Hat and CentOS Linux distributions.