Workrave is a program that assists in the recovery and prevention of Repetitive Strain Injury (RSI).

EyeDefender is a freeware rest reminder designed to prevent Computer Vision Syndrome (CVS) resulting from working on a computer for hours.

RSIBreak takes care of your health and regularly breaks your work to avoid repetitive strain injury (RSI).

Time Out is a handy break reminder tool for Mac.

EyeLeo is a handy PC application that reminds you to take a break for your eyes.