Krita is a professional free and open source painting program.

Clip Studio Paint (Manga Studio or ComicStudio) is a family of software applications for Mac OS X and Microsoft Windows used for the digital creation of comic…

Mischief is a sketching, drawing, and painting software for Mac OSX and Windows.

MyPaint is an easy-to-use painting program which works well with Wacom graphics tablets and other similar devices.

MediBang Paint is a free digital painting and comic creation software.

Animation Paper is a handwritten animation software.