Lutris is a gaming platform for Linux. It supports as many games as possible for a wide variety of platforms including native games, Windows, Playstation, Gamecube, etc.
License: Open Source
CrossOver is a commercial solution focused on running Windows applications on Linux and macOS with an easy-to-use interface and good support for popular applications. In contrast, Lutris is a free and open-source gaming platform that supports a vast range of games, including native Linux games, but may require more technical knowledge to set up and optimize.