Lutris is a gaming platform for Linux. It supports as many games as possible for a wide variety of platforms including native games, Windows, Playstation, Gamecube, etc.
License: Open Source
Itch.io is primarily a platform for indie game distribution, offering DRM-free games and a user-friendly interface for both developers and players. In contrast, Lutris is an open-source game manager that focuses on installing and managing games from various sources, including Windows games on Linux, and provides extensive customization options.