Lutris is a gaming platform for Linux. It supports as many games as possible for a wide variety of platforms including native games, Windows, Playstation, Gamecube, etc.
License: Open Source
PlayOnLinux (PlayOnMac) is primarily focused on running Windows applications and games on Linux with a user-friendly approach, making it suitable for beginners. In contrast, Lutris is more versatile, supporting both Windows and native Linux games with advanced features and customization options, catering to more experienced users.