Lutris is a gaming platform for Linux. It supports as many games as possible for a wide variety of platforms including native games, Windows, Playstation, Gamecube, etc.
License: Open Source
Wine is a compatibility layer that allows Windows applications to run on Unix-like operating systems, while Lutris is a gaming platform that manages and simplifies the installation of games on Linux, often utilizing Wine for Windows games. Wine focuses on application compatibility, whereas Lutris offers a broader gaming management experience.