Node.js is an open-source, cross-platform JavaScript run-time environment for executing JavaScript code server-side. Developed by Joyent, Inc.
License: Open Source
ASP.NET is a powerful framework best suited for enterprise-level applications with a focus on security and strong typing, while Node.js excels in performance and scalability, particularly for real-time applications. The choice between the two largely depends on the specific project requirements, team expertise, and preferred development environment.