NW.js (node-webkit) lets you call all Node.js modules directly from DOM and enables a new way of writing applications with all Web technologies. Developed by Roger Wang
License: Open Source
Appcelerator Titanium is primarily focused on mobile app development with strong native API access and rich UI components, making it suitable for mobile-first applications. In contrast, NW.js excels in creating desktop applications using web technologies, offering excellent performance and real-time capabilities, but lacks native mobile support.