nvALT 2 is a fork of the original Notational Velocity with some additional features and interface modifications, including MultiMarkdown functionality. Developed by Brett Terpstra
License: Open Source
The Guide offers a more feature-rich experience with support for rich media and advanced organization, making it suitable for users who need more functionality, while nvALT focuses on simplicity and speed, catering to those who prefer a lightweight, text-based note-taking approach.