RetroArch is a versatile multi-console emulator with extensive customization and features, while DeSmuME is focused on providing an accurate and user-friendly experience specifically for Nintendo DS games.
RetroArch
Pros:
Multi-platform support (Windows, macOS, Linux, Android, etc.)
Supports a wide range of emulators for various consoles
Highly customizable interface and settings
Built-in shaders and filters for enhanced visuals
Online multiplayer capabilities
Cons:
Can be complex to set up for beginners
Performance issues with some cores
Might require additional configuration for optimal use
DeSmuME
Pros:
Specifically designed for Nintendo DS emulation
Accurate emulation of DS hardware features
User-friendly interface
Support for touchscreen controls
Save state functionality with multiple save slots
Cons:
Limited to Nintendo DS games
Less versatility compared to multi-console emulators