WeeChat Alternatives for Mac OS X

Pidgin is a free and open-source multi-protocol instant messaging client designed to connect users across various chat networks with a single application. It's highly extensible through plugins and supports a wide range of protocols including XMPP, ICQ, and IRC.

Adium is a free and open-source instant messaging client for macOS, designed to connect to multiple chat networks simultaneously. Supporting protocols like Jabber (XMPP), Google Talk, AOL Instant Messenger (AIM), ICQ, MSN Messenger, and Yahoo! Messenger, Adium provides a unified interface for all your conversations.

Irssi is a highly customizable command-line IRC client popular among power users and system administrators for its extensibility and efficiency.

Colloquy is more than just a loyalty platform; it's a comprehensive customer engagement and data analytics solution designed to foster deep relationships and drive business growth. It provides tools for managing customer loyalty programs, facilitating direct communication, and deriving actionable insights from customer data.

KVIrc is a versatile and highly customizable graphical IRC client available for Linux, Unix, macOS, and Windows. It is designed to cater to both seasoned IRC users seeking advanced control and newcomers looking for a user-friendly interface to connect to various IRC networks.

Smuxi is a feature-rich, cross-platform IRC client designed with productivity and usability in mind. Inspired by the command-line power of Irssi, it provides a graphical interface for seamless communication across multiple networks including IRC, XMPP, and Twitter.

Textual is a premium Internet Relay Chat (IRC) client exclusively designed for macOS. It provides a user-friendly interface, extensive customization options through themes and plugins, and robust support for common IRC features, aiming to offer a modern and polished chat experience.