Mac OS X Softwares to Frame by Frame Animation

ENIGMA is an open-source game development platform and compiler, coupled with the LateralGM IDE. It allows users to create 2D and 3D games using a flexible scripting language and visual programming tools, offering compatibility with existing Game Maker projects and supporting cross-platform deployment.

Pencil2D is a free and open-source 2D animation software for Windows, macOS, and Linux. It offers a straightforward platform for creating traditional hand-drawn animations using vector and raster graphics.

Tupi is a free and open-source 2D animation software designed with beginners and enthusiasts in mind. It provides a user-friendly environment for creating traditional frame-by-frame animations and offers vector-based drawing tools.

Moho (formerly Anime Studio) is a powerful vector-based 2D animation software favored by both beginners and professionals. It specializes in character rigging, cut-out animation, and traditional frame-by-frame workflows, offering a comprehensive suite of tools for creating engaging 2D animations.

OpenToonz is a powerful, open-source 2D animation software widely used in professional studio production and by independent artists alike. It offers a comprehensive suite of tools for vector and raster drawing, frame-by-frame animation, bone rigging, complex effects, and scanned drawing cleanup.

MediBang Paint is a feature-rich, free digital painting and comic creation software available across multiple platforms. It provides a comprehensive toolkit for artists of all levels, from sketching and illustration to manga and comic production.

Adobe Animate CC, part of the Adobe Creative Cloud suite, is a powerful multimedia authoring and animation tool. It enables the creation of interactive animations for games, TV shows, and web applications. Supporting a wide range of output formats including HTML5 Canvas, WebGL, and SVG, Animate CC is a versatile tool for animators and web developers.