SymPy is a Python library for symbolic computation. It provides computer algebra capabilities either as a standalone application, as a library to other applications, or live on the web as SymPy Live or SymPy Gamma.
License: Open Source
MATLAB is a powerful commercial software primarily focused on numerical computations and engineering applications, whereas SymPy is an open-source Python library that excels in symbolic mathematics and is highly customizable. While MATLAB offers extensive built-in support and a user-friendly interface, SymPy provides flexibility and integration with the broader Python ecosystem.