Vifm is a lightweight, command-line based file manager that is highly customizable and ideal for users who prefer keyboard navigation and scripting. In contrast, NexusFile provides a rich graphical user interface with a dual-pane view, making it more user-friendly for those who prefer visual file management. Overall, Vifm is better for tech-savvy users, while NexusFile caters to those looking for a more traditional file management experience.