MATLAB
Commercial
MATLAB (matrix laboratory) is a multi-paradigm numerical computing environment and fourth-generation programming language.
Mathematica
Commercial
Wolfram Mathematica (usually termed Mathematica, Mathematica software suite) is a mathematical symbolic computation program.
SciPy & Numpy
Open Source
NumPy and SciPy are open-source add-on modules to Python that provide common mathematical and numerical routines in pre-compiled, fast functions.
wxMaxima
Open Source
Maxima is a computer algebra system based on a version of Macsyma.
IBM SPSS Statistics
Commercial
SPSS Statistics is a software package used for logical batched and non-batched statistical analysis.
R (programming language)
Open Source
R is an open source programming language and software environment for statistical computing and graphics that is supported by the R Foundation.
Sage
Open Source
Sage offers business management, bookkeeping & accounting software to meet any business need, from small to midsized businesses.
Maxima
Open Source
Maxima is a fairly complete computer algebra system written in Lisp with an emphasis on symbolic computation.
Maple
Commercial
Maple is a symbolic and numeric computing environment, and is also a multi-paradigm programming language.
Compare SymPy with alternatives
Compare R (programming language) and SymPy and decide which is most suitable for you.
Compare SciPy & Numpy and SymPy and decide which is most suitable for you.
Compare IBM SPSS Statistics and SymPy and decide which is most suitable for you.